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发明公开
CN107266303A 合成方法 有权 转让

合成方法
摘要：
描述了通过使3-(5-乙氧基庚-1-基)环戊烯与二氯乙烯酮反应来合成6-(5-乙氧基庚-1-基)双环[3.3.0]辛烷-3-酮的方法。使所得反应产物与乙酸和锌反应以产生4-(5-乙氧基庚-1-基)双环[3.2.0]庚烷-6-酮和4-(5-乙氧基庚-1-基)双环[3.2.0]庚烷-7-酮，使其与三甲基碘化锍反应以产生2-(5-乙氧基庚-1-基)螺[双环[3.2.0]庚烷-6，2’-环氧乙烷]和4-(5-乙氧基庚-1-基)-螺-[双环-[3.2.0]庚烷-6，2’-环氧乙烷]。使二者与碘化锂反应以产生目的产物。还描述了合成6-(5-甲氧基庚-1-基)双环[3.3.0]辛烷-3-酮的方法。
摘要（英）：

The invention provides a method for synthesizing 6-(5-ethoxy-hept-1-yl)bicyclo[3.3.0] octane-3-one from 3-(5-ethoxy-hept-1-yl) cyclopentene and dichloroketene by reacting. A reaction product reacts with acetic acid and zinc, then 4-(5-ethoxy-hept-1-yl)bicyclo[3.2.0] heptane-6-one and 4-(5-ethoxy-hept-1-yl)bicyclo[3.2.0] heptane-7-one are produced and react with trimethylsulfonium iodide, and 2-(5-ethoxy-hept-1-yl) spiro [bicyclo[3.2.0] heptane-6,2'-oxirane] and 4-(5-ethoxy-hept-1-yl)-spiro-[bicyclo[3.2.0] heptane-6,2'-oxirane] are produced. The two products react with lithium iodide, and the target product is produced. The invention further provides a method for synthesizing 6-(5-methoxy-hept-1-yl) bicyclo[3.3.0] octane-3-one.

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