The invention discloses an optical coupling amplifier circuit. The optical coupling amplifier circuit comprises a pre-amplifier, an operational amplifier, a post amplifier, a first optocoupler OC1 and a second optocoupler OC2; an input signal Vi enters the operational amplifier through the pre-amplifier, a current signal is output after an output signal after being amplified by the operational amplifier passes through the first optocoupler OC1 and the second optocoupler OC2, and then passes through a fifth resistor to output a voltage signal, and the voltage signal is amplified through the post amplifier to output a signal Vo. The optical coupling amplifier circuit is high in current transfer ratio and good in linear transmission performance.