The invention provides a two-in-one toothbrush used in travel. The toothbrush and toothpaste are combined into one body; when the two-in-one toothbrush is in use, only a toothbrush cover cap needs to be pulled off, and a toothbrush handle is rotated to be placed in a spiral opening at the tail part of the toothpaste; and therefore, the two-in-one toothbrush is very convenient to carry and use.