The invention relates to the field of technologies for processing labor protection appliances, in particular to a labor protection shoe sewing machine which comprises a framework. A first rotary shaft is rotationally arranged on the inner wall of the framework, a cam is welded on the first rotary shaft, a transverse rod is rotationally arranged on the cam, a transverse slider is welded on the transverse rod, a vertical rod is welded on the top of the framework, a vertical slider is slidably arranged on the vertical rod, a transverse straight slot is formed in the vertical slider, the transverse slider is slidably connected into the straight slot, a needle is further arranged on the vertical slider, a motor is arranged in the framework, and a first belt is arranged between an output shaft of the motor and the first rotary shaft in a connected manner; a glue box is arranged below the cam, a slide plate is slidably arranged in the glue box, a spring is arranged between the slide plate and the bottom of the glue box in a connected manner, a lug is connected with the top of the slide plate, a vertical plate is slidably arranged on the inner side wall of the glue box, the top of the vertical plate is connected onto the slide plate, a glue spray hole is formed in the vertical plate, and a glue spray pipe is connected onto the side wall, which is close to the vertical plate, of the glue box; a tray is further arranged on the framework. The labor protection shoe sewing machine has the advantages that shoe sole and shoe upper adhering and sewing synchronous processing can be implemented, and accordingly the processing efficiency can be improved.