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发明公开
CN107200765A 一种牛磺熊去氧胆酸合成方法 失效 - 放弃专利权

一种牛磺熊去氧胆酸合成方法
摘要：
本发明公开一种牛磺熊去氧胆酸合成方法，是以家禽胆汁为原料，首先经溶解除杂、脱脂、除蛋白、酸化、过离子交换树脂等工艺步骤，获得高纯度牛磺鹅去氧胆酸；然后通过牛磺鹅去氧胆酸的7‑羟基选择性氧化，获得3α‑羟基‑7‑酮基‑胆烷酰‑N‑牛磺酸；再通过3α‑羟基‑7‑酮基‑胆烷酰‑N‑牛磺酸的7‑酮基选择性还原，获得3α,7β‑二羟基胆烷酰‑N‑牛磺酸，最后通过重结晶提纯，获得高纯度的牛磺熊去氧胆酸。本发明采用廉价的原料，通过两步反应得到高附加值的牛磺熊去氧胆酸，化学合成路线短，产率高、目标产物纯度高，工艺简单可控，杂质少，减少酸和碱的排放，绿色环保，有利于实现产业化，在制药领域具有很好的应用前景。
摘要（英）：

The invention discloses a tauroursodeoxycholic acid synthesis method. The method includes: taking poultry bile as a raw material, and performing process steps of dissolving, decontaminating, degreasing, deproteinizing, acidifying, treatment through ion-exchange resin and the like to obtain high-purity taurochenodeoxycholic acid; performing 7-hydroxyl selective oxidation of the taurochenodeoxycholic acid to obtain 3alpha-hydroxyl-7-keto-cholan-24-oyl-N-taurine; performing 7-keto selective reduction of 3alpha-hydroxyl-7-keto-cholan-24-oyl-N-taurine to obtain N-(3alpha,7beta-dihydroxy-5-beta-cholan-24-oyl)-taurine; finally performing re-crystallization and purification to obtain high-purity tauroursodeoxycholic acid. Cheap raw materials are adopted for acquisition of high-additional-value tauroursodeoxycholic acid through two-step reaction, short chemical synthesis route, high yield, high target product purity, simple and controllable process, few impurities, reduction of acid and alkaline emission and environmental friendliness are realized, industrialization can be realized beneficially, and the method has a promising application prospect in the pharmaceutical field.

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