The invention discloses a method for evaluating the operation efficiency of a multi-AGV scheduling system. The method comprises the steps: respectively collecting the AGV mean operation speed, AGV mean load ratio and cargo mean operation time of different AGV scheduling systems as operation efficiency impact factors under the condition that the number of AGVs and the total number of cargo tasks are not changed; employing an entropy method, carrying out calculation according to the collected operation efficiency impact factors, and obtaining a comprehensive evaluation coefficient which can be used for the evaluation of the operation efficiency of each scheduling system; comparing the advantages and disadvantages of different scheduling systems through the comprehensive evaluation coefficients of operation efficiency, so as to select the optimal AGV scheduling system for a specified factory.