The invention discloses an anti-cardiac-failure compound, a preparation method thereof and an application of the compound in the cardiac failure treatment. The provided preparation method has the advantages of simple and easy process, less by-products, easy separation and purification, and high yield. A product obtained by a nuclear magnetic resonance method accords with the target product. The anti-cardiac-failure compound has the good curative effect in a cardiac failure animal model induced by anthracycline anti-cancer drugs, such as adriamycin, and has the extensive application prospect.