The invention relates to a spherical medical treatment grinding device. The spherical medical treatment grinding device comprises a grinding body and a grinding ball; a grinding groove sinking inwards is formed in the grinding body, an elastic layer is arranged on the grinding groove, an airtight liquid storage cavity is defined by the elastic layer and the grinding groove, and the liquid storage cavity is filled with adjusting liquid; an adjusting cavity is further arranged on the grinding body, the adjusting cavity and the liquid storage cavity are in airtight communication, and a controller is arranged on the adjusting cavity; grinding sheets arranged in an arrayed manner at equal intervals are arranged on the outer surface of the elastic layer, the cross section of the grinding sheets are in sector shape, and the grinding sheets can be spliced into half chapping spherical surfaces with coincident radius of curvature; and the radius of curvature of the chapping spherical surfaces is matched with the radius of curvature of the grinding ball. By means of the spherical medical treatment grinding device, the grinding speed and grinding effect can be effectively improved, medicine particle outburst is effectively prevented, the grinding safety degree is improved, and medicine waste is prevented.