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发明公开
CN107129981A 氨基酸氧化制备酮酸用氨基酸氧化酶负载型催化剂 无效 - 驳回

氨基酸氧化制备酮酸用氨基酸氧化酶负载型催化剂
摘要：
本发明公开了一种氨基酸氧化制备酮酸用氨基酸氧化酶负载型催化剂，涉及生物酶催化剂技术领域，其制备方法包括如下步骤：(1)共固定剂的制备，(2)复合载体的制备，(3)活化载体的制备，(4)氨基酸氧化酶负载型催化剂的制备。本发明所制氨基酸氧化酶能显著提高氨基酸转化为酮酸的收率，尤其将由头孢菌素C制备酮酸中间体的收率提高到95％以上，且产品中酮酸中间体的纯度达到99％以上。
摘要（英）：

The invention discloses an amino-acid oxidase supported catalyst used for oxidizing amino acid to prepare ketonic acid and relates to the technical field of biological enzyme catalysts. A preparation method of the amino-acid oxidase supported catalyst includes the steps of firstly, preparing a co-immobilization agent; secondly, preparing a compound carrier; thirdly, preparing an activating carrier; fourthly, preparing the amino-acid oxidase supported catalyst. The prepared amino-acid oxidase supported catalyst can evidently increase the yield of the ketonic acid converted from the amino acid, the yield of an ketonic acid intermediate prepared from cephalosporin C is increased to above 95%, and the purity of the ketonic acid intermediate reaches above 99%.

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