A combination of external medicines of an active ingredient I applied to a lesion and an active ingredient II applied to both sides of the chest. The active ingredient I consists of an immune protein powder and a traditional Chinese medicine for treating corresponding diseases. The active ingredient II consists of an immune protein powder and a traditional Chinese medicine for nourishing the liver and kidney. The combination of external medicines can be used to treat hyperplasia of mammary glands, prostatitis and pleural effusion. The medicine can effectively avoid side effects, shorten the treatment time, reduce the amount of the medicine, and has features of symptomatic treatment, high cure rate and is convenient to use.