The invention relates to a production method and application of a Na<3>V<2>(PO<4>)<3>-based quasi-symmetric high-voltage sodium ion secondary battery. The production method comprises the following steps of S1, preparing single-crystal Na<3>V<2>(PO<4>)<3> material used as a positive electrode material by a conventional anti-solvent recrystallization method; S2, assembling the single-crystal Na<3>V<2>(PO<4>)<3> and elemental sodium into a sodium ion button-type half cell, namely, assembling according to a sequence of a positive electrode shell, a current collector, the Na<3>V<2>(PO<4>)<3> material, a separator, a sodium sheet, a current collector and a negative electrode shell by employing a CR2016 button-type cell shell, employing a sodium perchlorate electrolyte, performing constant-current discharging, similarly performing constant-current charging, and taking out the product to obtain the sodium ion button-type half cell; and S3, assembling the positive electrode material and a negative electrode material into the sodium ion secondary battery according to a mass ratio by conventional method. The production method has the beneficial effects that the quasi-symmetric high-voltage sodium ion secondary battery has excellent electrochemical performance, is high in discharge voltage and energy density and can be used in a large-scale energy storage device and relevant energy storage application.