The invention discloses a preparation method of a pure-titanium denture framework. The preparation method of the pure-titanium denture framework comprises the following steps: 1, performing model observation: scanning a denture model to generate an STL file; 2, performing design, comprising selecting an insertion path, customizing to fill undercut and determining a clamping ring position by using CAD software according to the requirements of customers; 3, determining a grid area and completely framework design; and 4, outputting designed data to a CAM equipment-high-speed cutting processing center, performing CNC cutting on a titanium cake and performing once forming to prepare the pure-titanium denture framework. According to the preparation method provided by the invention, processes of duplicating work models and embedding casting are omitted, the production cycle is shortened, efficiency is improved, the digital flow process is easy to master, design is quick and labor-saving, an user interface is friendly and intuitive, the precision and driving fit of the framework are greatly improved, and the comfort level of a user is guaranteed to the maximal degree; furthermore, the framework has attractive appearance, carved outline, high adaptability and good user experience, and flaws are not seen under X-ray transmission.