The invention provides a production process of slippers used for preventing and treating beriberi. The production process includes the following steps that 1, wooden shoe boards aresoaked in Chinese medicine liquid for 6-10 hours, after air-drying, the lower end faces of the wooden shoe boards is fixed with rubber shoe boards, and shoe soles are obtained, wherein the Chinese medicine liquid is prepared from 10-15 parts of fructus cnidii, 3-7 parts of saposhnikovia divaricata, 2-6 parts of asarum, 6-12 parts of bamboo leaves, 2-5 parts of Chinese honeylocust fruits, 3-6 parts of cortex phellodendri amurensis and 2-4 parts of aloe juice; 2, rubber shoe uppers are prepared, grooves are formed in the upper end faces of the rubber shoe uppers, groove covers matched with the grooves are installed, the portions, at the lower ends of the grooves, of the rubber shoe uppers are provided with several air vents, and Chinese medicine bags filled with Chinese medicine powder are placed in cavities formed by the grooves and the groove covers, wherein the Chinese medicine powder is prepared from 10-15 parts of mint, 3-10 parts of radix angelicae, 3-8 parts of honeysuckle, 2-6 parts of perilla nankinensis, 3-6 parts of licorice rod, 3-5 parts of cortex acanthopanacis and 5-10 parts of folium artemisiae argyi; 3, the rubber shoe uppers are fixed to the shoe soles. The slippers obtained through the production process have excellent effects on the prevention and treatment of beriberi, meanwhile are comfortable to wear and have a good mosquito repellent effect.