The present invention relates to a service response method and a service system for accessing an intelligent substation to a control master station. The method comprises the steps that a client of a service consumption end requests a service from an output agent; the output agent inquires a domain management center of the service consumption end and sends a service request to an input agent of a service provider end according to positioning information after receiving returned positioning information; the input agent sends a request to position the service to a service management center of the service provider end, and sends the service request to the service provider after receiving returned service provider information; and the input agent receives response information of the service provider, and then forwards the response information to the output agent of the service consumption end, and the output agent of the service consumption end forwards the service response information to the client of the service consumption end. Through adoption of the service response method and service system, the communication framework between the intelligent substation and the master station is expanded, and a more flexible communication manner is provided to meet the increasing interaction business demands between the master station and the substation.