An automatic medicine packing machine is provided. The automatic medicine packing machine includes a main body provided with an installation space formed therein and a hopper formed in the lower portion thereof to allow medicines to be dropped into the hopper, cassette supports installed in the installation space and having mounting positions of cassettes to accommodates the medicines, display units configured to receive a driving signal transmitted from the outside and then to display the cassette mounting positions to the outside, and a controller configured to predetermine information on selected medicines and reference mounting positions of the selected medicines and to, if medicine information is input from the outside, display positions of the cassettes to be mounted based on the input medicine information to the outside through the display units.