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发明公开
CN107050457A 游离酸形式的Ω‑3多不饱和脂肪酸的富含DPA组合物 无效 - 撤回

游离酸形式的Ω‑3多不饱和脂肪酸的富含DPA组合物
摘要：
本发明涉及一种游离酸形式的Ω‑3多不饱和脂肪酸的富含DPA组合物。具体而言，本发明提供采用游离酸形式的多不饱和脂肪酸的富含DPA的药物组合物、它们应用的治疗方法、和从鱼油中精制这些组合物的工艺。还提供通过他汀类与本文中所描述药物组合物的辅助给药来治疗高甘油三酯血症(200 mg/dL‑500 mg/dL)的方法。其中更多的治疗方法包括：增加血浆EPA:AA比率的治疗、降低载脂蛋白CⅢ(Apo CⅢ)水平的治疗、和降低并防止对血小板聚集抑制剂的耐药性的治疗。
摘要（英）：

The present invention relates to DPA-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form, in particular to DPA-enriched pharmaceutical compositions of polyunsaturated fatty acids in free acid form, therapeutic methods for their use, and processes for refining the compositions from fish oil are presented. Also provided are methods of treating hypertriglyceridemia (200 mg/dL-500 mg/dL) by adjunctive administration of a statin and the pharmaceutical compositions described herein. Further treatment methods include, inter alia, treatments to increase plasma EPA:AA ratios, treatments to decrease ApoCIII levels, and treatments to reduce or prevent resistance to platelet aggregation inhibitors.

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