The invention discloses a pre-pressing self-tightening joint for an ocean composite flexible pipe. The pre-pressing self-tightening joint comprises an outer sleeve ring, a wedge ring, a locking ring, an axe shaft and an inner pressing ring; the outer side of the wedge ring is sleeved with the outer sleeve ring, a seal part is arranged between the outer sleeve ring and the wedge ring, the front end of the outer sleeve ring is in a conical shape, the rear end of the outer sleeve ring is in threaded connection with the locking ring, the locking ring is arranged between the outer sleeve ring and the axe shaft, one end of the axe shaft is connected with the wedge ring, the other end of the axe shaft is connected with a flange disc, the inner pressing ring is arranged on the innermost layer of the joint, the rear end of the inner pressing ring is fixedly connected with the inner wall of the axe shaft, a gap containing the end of the flexible pipe exists between the inner pressing ring and the wedge ring, and the inner pressing ring and the wedge ring extrude to form clamping force to limit pipeline displacement. The mechanical compressing manner is adopted, through assembly, pre-pressure is formed and locked, under the outer load, the pipeline compressing effect can be increased, the structural strength is high, the property is good, use and operation are convenient, the joint can be applied to the use environments of the deep ocean, the high temperature, the high pressure and the like, and the wide popularization value and the partial value can be achieved.