The invention relates to preparation and application of a composite magnetic hydroxyapatite macro-sphere adsorbing material and belongs to the fields of preparation of composite adsorbing materials and water treatment application. The preparation method comprises the following steps: modifying a carboxy group on the surface of prepared magnetic ferroferric oxide, and introducing calcium ion into the reaction system, so that the calcium ion can be adsorbed by carboxylate radical ion on the magnetic sphere surface, and finally monodisperse magnetic ferroferric oxide is formed; coating a porous inert medium on the magnetic sphere surface, and successfully preparing the composite magnetic hydroxyapatite macro-sphere adsorbing material. The material has the characteristics of large macro-sphere size and excellent magnetic response and can be simultaneously applied to large-scale industrial water pollution treatment and small-scale lab application; and moreover, nanoparticles coated in macro-spheres can effectively enlarge the specific surface area for adsorption, and the adsorption capacity is improved. The composite magnetic hydroxyapatite macro-sphere adsorbing material prepared by the method disclosed by the invention is simple in preparation method and high in reproducibility, and the prepared material has higher adsorption capacity on metal ions in the water body.