The invention discloses anti-scraping indication ink and a preparation method thereof. CTAB and P123 serve as a mixed template agent, aluminum isopropoxide serves as an aluminum source, a certain amount of rare earth elements are added, and a sol-gel method is adopted to obtain rare earth element doped mesoporous aluminum oxide; a diluent and a wetting dispersant are added in the prepared mesoporous aluminum oxide and the mesoporous aluminum oxide is ground to make a nano-alumina additive; the additive is added into an indication ink system, adhesion of the indication ink on a base material is remarkably improved, scraping resistance is greatly improved, and a shortcoming that chemical indicator card ink in a package on the market drops and transfers easily is overcome. The indication ink and the method for preparing the indication ink are simple and easy to operate, the manufacturing cost is low, an effect is remarkable, and the anti-scraping indication ink is suitable for large-scale industrial production and has very high practicality and wide applicability.