The invention discloses a myricetin derivative containing piperazine amides. The myricetin derivative containing piperazine amides is characterized in that a general formula of the myricetin derivative is as shown in the description. In the formula, R1 represents more than one hydrogen atom, methoxy, nitryl, methyl, trifluoromethyl or halogen atoms at ortho position, meta position or para position of benzene ring. The compound has certain inhibition activity on hepG2 cells and SGC7901 cells, is low in toxicity to normal cells, and can be used for preparing anti-tumor medicines.