The invention discloses a preparation method of high-adhesion high-dispersion titanium dioxide photocatalytic film. The method comprises the following steps: coating a roughened glass sheet with organic silicone resin, secondly, coating the surface of a resin layer with titanium dioxide, and finally performing the gradient pressurizing sealing heating reaction and high-temperature sintering reaction to obtain a photocatalytic film material. The titanium dioxide catalytic film provided by the invention has good fastness, and can meet the requirement on water flow impact; and meanwhile, the titanium dioxide has good exposure effect and has good dispersity.