A totally-prefabricated spliced type reinforced concrete slope protection module assembly comprises a prefabricated concrete frame and a protective skeleton inside the prefabricated concrete frame. The prefabricated concrete frame and the protective skeleton are formed in a prefabricated spliced manner. The protective skeleton is formed by splicing a plurality of precast blocks. Each precast block comprises at least one set of main skeletons and auxiliary skeletons. The two ends of each main skeleton are of a concave-convex structure, the two sides of each main skeleton are provided with second wet joints, the end portions of the second wet joints are of a concave face structure, and the end portion of each auxiliary skeleton is of a convex face structure. The invention further provides a construction process of a protection module. The construction process comprises frame splicing and precast block splicing. The structure is simple, installation is facilitated, an existing slope protection module assembly of an integrated structure is changed into the spliced slope protection module assembly, spliced modules are prefabricated and then assembled on site, the project quality can be monitored conveniently, the time for construction at places with relatively high risks is shortened for workers, and the risks are reduced; and meanwhile the wet construction on site is little, and the influence on the environment is small.