The invention relates to a display panel drive method and a display device. The method comprises the steps: dividing pixels of the same color on a display panel into a plurality of pixel pairs, wherein each pixel pair comprises a first subpixel and a second subpoxel; sequentially displaying each frame through two images; obtaining a first voltage signal and a second voltage signal which are not equal and corresponding to each subpixel, wherein the positive visual angle mixed brightness is equivalent to the positive visual angle brightness of an image input signal; driving the first subpixel of the first image through a first voltage signal of the first subpixel or the second subpixel, and driving the second subpixel of the first image through a second voltage signal of the first subpixel or the second subpixel; driving the first subpixel of the second image through the second voltage signal of the first subpixel or the second subpixel, and driving the second subpixel of the second image through the first voltage signal of the first subpixel or the second subpixel. The method irons out the defect of aberration caused by the mismatching of the big-visual-angle refractive index of the display panel.