The invention provides a serial fan set with a frame. The serial fan set comprises a first fan, a second fan and the hollow frame. The frame is provided with a first containing space, a second containing space, an inlet, an outlet and an oblique channel which is located between the first containing space and the second containing space in a communicating mode. The first containing space and the second containing space are located in the adjacent inlet and the adjacent outlet respectively and used for containing the opposite first fan and the opposite second fan. A first virtual center line of the first fan intersects with a second virtual center line of the opposite second fan in the oblique channel.