The invention provides an intelligent and safe monitoring system for an office building. The system comprises a main control platform based on the Internet of Things, an intelligent fire fighting unit, a security and protection monitoring unit, an intelligent illuminating unit, a multimedia display system, a CAN bus and a CAN bus access unit. Security and protection can be performed on the office building region; all-around monitoring and maintenance are performed on the fire fighting; meanwhile, by improving sub systems, working efficiency and accuracy of security and protection and fire fighting facilities are effectively improved; and the system has very practical and positive meaning.