知搜-全球专利检索

  1. 登录
  2. 注册
发明公开
CN106967014A 一种茶尺蠖性信息素的合成方法 无效 - 撤回

一种茶尺蠖性信息素的合成方法
摘要：
本发明茶尺蠖性信息素的合成方法，属于药物合成领域，具体为：(2E)‑2‑烯基‑5‑炔基‑1‑辛醇在金鸡纳碱类催化剂作用下，得到手性5‑炔基‑1,2,3‑三辛醇。在碱性条件下，此三辛醇与对甲苯甲酰氯反应生成1,2‑环氧‑3‑对甲苯磺酸酯‑5‑辛炔，再在碱性条件下，与1‑癸炔、三氟化硼反应生成3,9‑二炔‑6‑对甲苯磺酸酯‑7‑十八醇。再与碳酸钾反应生成6,7‑环氧‑3,9‑二炔十八烷，最后，催化加氢得到茶尺蠖性信息素。本发明的茶尺蠖性信息素的合成方法，操作简单，条件温和，适合大量生产。
摘要（英）：

The invention discloses a synthetic method of tea geometrid tea geometrid, and belongs to the drug synthesis field. Particularly, (2E)-2- alkenyl-5-alkynyl-1-octanol is prepared to be chirality 5- alkynyl-1, 2, 3-trioctanol under the function of cinchona alkaloid catalyst. Under the alkali condition, the trioctanol and para-toluene formyl chloride are reacted to generate 1, 2-epoxy-3- tosylate-5- octyne; under the alkali condition, the 1, 2-epoxy-3- tosylate-5- octyne and 1-decyne, boron trifluoride are reacted to generate 3, 9-diyne-6-tosylate-7-octadecanol. Then the 3, 9-diyne-6-tosylate-7-octadecanol is reacted with potassium carbonate to generate 6, 7-epoxy-3, 9-diyne octodecane; at last, tea geometrid tea geometrid is acquired through catalytic hydrogenation. The synthetic method of tea geometrid tea geometrid is simple in operation, gentle in condition, and suitable for massive production.

0/0