The invention discloses a synthesis method of anti-aids drug intermediates diazoketone and chlorone. Main raw materials include N-methyl-N-nitroso-p-toluene thiamine and N-Cbz-L-phenylalanine. The synthesis method comprises the main steps of diazomethane preparation, N-methyl-N-nitroso-p-toluene thiamine preparation, diazoketone preparation and chlorone preparation; reaction is performed in a microreactor. The synthesis method is relatively high in yield and is conductive to industrialized and amplified generation. In addition, due to the fact that diazomethane is prepared in a microchannel and converted in situ, the diazoketone is conveniently and safely prepared. The method adopting the synthetic route is simple in reaction condition, the raw materials are easy to obtain, and what's more important is that the problems of flammable and explosive possibility, generation of high toxic gas, complex preparation steps and the like caused in the diazomethane using process are avoided.