The invention discloses simple synthesis of a salt crystallization inhibitor and application thereof and solves the problems that in the prior art, the process is complicated, the cost is too high and the like. The synthesis is characterized by comprising the following steps of: by taking ethylene glycol and nitrilotriacetic acid as raw materials, performing a heating reaction; preparing a primary inhibit aminoacetamide by taking silochrom as a water absorbent; then uniformly mixing the raw materials with a surfactant to prepare a total crystallization inhibitor; and then adding the total crystallization inhibitor into a salt solution in proportion to generate an effect of inhibiting crystallization of saturated salt. The synthesis has the advantages of being simple, simple in formula, low in cost, obvious in using effect and the like, and can be widely applied to the crystallization inhibiting field of high concentration inorganic salt solutions in industries of chemistry, chemical engineering, petroleum and etc.