The invention designs low-heat antibacterial bone cement, as well as a preparation method and applications thereof. The bone cement includes a powder and a liquid, wherein ratio of the powder to the liquid is 3 g to 1.5 ml. The powder is composed of gentamycin- or tobramycin-doped polymethyl methacrylate and nano-scale hydroxyapatite, wherein the mass percentage ratio of the nano-scale hydroxyapatite is 5-10% and the mass percentage ratio of the gentamycin- or tobramycin-doped polymethyl methacrylate is 90-95%; the liquid is water. When the bone cement is implanted in body, the gentamycin or tobramycin is slowly released, so that the bone cement has excellent antibacterial effect. The bone cement has high antibacterial and pressure resistant effects and is used for orthopaedic filling in various types, and exchange arthroplasty.