The invention relates to the field of treatment for organic waste, and discloses a treatment process for antibiotic mycelium residue. The treatment process comprises the following steps: degrading the antibiotic mycelium residue to be treated at 100-260 DEG C and under an airtight condition, then separating degradation products to obtain a solid-phase material flow and a gas-phase material flow, and carrying out post-treatment on the gas-phase material flow. Through the technical scheme, organic nutritional ingredients in the antibiotic mycelium residue can be effectively reserved while residual antibiotics in the antibiotic mycelium residue are effectively degraded, so that a good precondition is provided for harmless utilization for the mycelium residue. Moreover, the process disclosed by the invention is capable of effectively avoiding the problem that the mycelium residue releases an offensive odour during the treatment process and after the treatment; and the treated mycelium residue is odour-free and environment-friendly.