The invention discloses a quantum dot core-shell synthesizer. The quantum dot core-shell synthesizer comprises a core/shell reaction region for core-shell reaction, the core/shell reaction region comprises at least one helical reaction tube, the inner wall of the helical reaction tube is provided with an approach groove opposite to the helical shape and enabling a reactant injected into the reaction tube to generate bubbling effect due to friction, a heating region wraps the front section of the core/shell reaction region, a cooling region wraps the back section of the core/shell reaction region, a plurality of injection inlets are formed in the front end of the core/shell reaction region, a plurality of plankton discharge outlets are formed in the back end of the core-shell reaction region, and a pressurizing device is connected with the front end of the core-shell reaction region. The invention further discloses a quantum dot core-shell synthesizing method. The quantum dot core-shell synthesizer is capable of improving stability and particle size uniformity of quantum dots and makes the quantum dots free of defects and quantum efficiency maximized so as to synthesize the quantum dots higher in sharpness and light-emitting efficiency.