The invention discloses a cyclohexanone preparation catalyst, and a preparation method and application thereof. The cyclohexanone preparation catalyst is characterized by comprising hybridization materials, wherein the hybridization materials comprise crystals and precious metal quantum dots positioned on crystal edges; the crystals are selected from at least one kind of crystals of alkaline-earth metal hydroxide crystals, alkaline-earth metal oxide crystals, alkaline-earth metal carbonate crystals and alkaline-earth metal hydrocarbonate crystals; the precious metal in the precious metal quantum dots is selected from at least one kind of metal from platinum group metals; or the precious metal in the precious metal quantum dots is alloy of at least two kinds of metals selected from platinum group metals. The catalyst has the advantages that the catalyst can be used for preparing the cyclohexanone through phenol catalysis and selective hydrogenation at normal temperature, normal pressure and water phase; the selectivity can reach 99 percent; the conversion rate exceeds 95 percent; the catalyst has the circulation stability.