The invention relates to a stepper motor drive module and a system with the module thereof. The stepper motor drive module comprises a key display circuit, a power management circuit, an internal central processing unit, an external pulse interface circuit and a drive control circuit; the stepper motor drive module is small in volume design, high in integration density, and integrates over 100 components for a PCB base plate only of the match box size. The PCB base plate is completed using the double-sided paster process, and the module integrates the power management circuit, the internal central processing unit, the drive control circuit, and the key display circuit, and the external wiring connector into one. The stepper motor driver module adopts a CAN bus communication and retains the original pulse input mode, and is flexible to use. By the stepper motor driver module, the research and development of the smart device can be quickly implemented, equipment lines are reduced, the development cycle is reduced, equipment costs are reduced, later stage maintenance is facilitated, and the equipment is made more stable.