The invention discloses a membrane key switch and a manufacturing method of a membrane key panel. The membrane key switch is composed of a printed circuit board and the membrane key panel covering the printed circuit board. The printed circuit board comprises a ground wire layer, a power layer and a plurality of signal layers in sequence from bottom to top. A TVS power protector is connected between the ground wire layer and the power layer. An ESD static electricity resistor is connected between the ground wire layer and the multiple signal layers. The membrane key panel sequentially comprises a first protection layer, an antistatic layer, a PET substrate, a pattern layer, a shielding layer, a second protection layer, a conducive adhesive layer and a button cushion layer from top to bottom; the ground wire layer of the printed circuit board is connected with the shielding layer and the antistatic layer of the membrane key panel. The TVS power protector is connected between the power layer and the ground wire layer so as to reduce instantly-generated electromagnetic interference, and the ESD static electricity resistor is connected between the signal lines and the ground wire, so that the static electricity phenomenon generated by the touch effect is reduced, and a switch membrane switch body is protected.