The invention discloses a universal type offset type self-adaptive mechanical and electrical safety lock. The universal type offset type self-adaptive mechanical and electrical safety lock is used for locking or unlocking special equipment. The universal type offset type self-adaptive mechanical and electrical safety lock comprises a mounting base which is in a cuboid shape and opened at the bottom, one end of the top wall of the mounting base is provided with a slide groove extending in the length direction of the mounting base, and the slide groove is provided with a locking mechanism for clamping and limiting the slide groove; the other end of the top wall of the mounting base is fixedly provided with a base in a hollow cubic shape, the bottom in the base is provided with an unlocking position travel switch, and the inner side wall of the base is provided with a locking position travel switch; the unlocking position travel switch and the locking position travel switch are both electrically connected to a control system of the special equipment. According to the universal type offset type self-adaptive mechanical and electrical safety lock, by rotating a hand wheel, locking rod is driven to trigger the unlocking position travel switch and the locking position travel switch, the purpose of locking or unlocking the special equipment is achieved, and the operation is convenient and fast.