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发明公开
CN106834501A 与中国儿童肥胖相关的单核苷酸多态性位点及其应用 有权

与中国儿童肥胖相关的单核苷酸多态性位点及其应用
摘要：
本发明涉及一种与中国儿童肥胖相关的单核苷酸多态性位点及其应用。本发明公开了一种与中国儿童肥胖相关的生物标志物，所述生物标志物包括以下中国儿童肥胖易感性SNP位点中的一种或两种：易感SNP位点(1)：rs1059491具体为chr16:28603655，c.704A>C，p.N235T；易感SNP位点(2)：rs768847893具体为chrX:3241682，c.2044C>T，p.R682C。本发明发现了两个易感SNP位点并研究了其在儿童肥胖辅助检测的应用前景，本发明提供的肥胖相关的基因位点可能是肥胖的早期生物标志物，为进一步研究肥胖的遗传分子机制，探索肥胖早期防治的药物靶点提供了新的方向。
摘要（英）：

The invention relates to a single nucleotide polymorphism sites related to obesity of Chinese children and application thereof. The invention discloses a biomarker related to obesity of Chinese children. The biomarker comprises one or two SNP sites of susceptibility to obesity of Chinese children, wherein the sites comprises susceptibility SNP site (1): rs1059491, or in concrete, the chr16: 28603655, c. 704A> C, p. N235T; susceptibility SNP site (2): rs768847893, or in concrete, the chrX: 3241682, c. 2044> T, p. R682C. According to the single nucleotide polymorphism sites related to obesity of Chinese children, two susceptibility SNP sites are found, and the application prospect of the sites in the auxiliary tests of children obesity is investigated. The gene sites related with obesity are possibly the early biomarkers of obesity, and provide a new direction for the further investigation of the genetic molecular mechanism of obesity and the exploration of drug targets for the early prevention of obesity.

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