The invention provides a man-machine interaction somatosensory vehicle. The man-machine interaction somatosensory vehicle comprises a vehicle body and two wheels arranged on the vehicle body. The wheels can rotate around the vehicle body in the radial direction. The vehicle body further comprises a supporting framework, two footrest devices, a first position sensor and a control device, wherein the two footrest devices are arranged on the supporting framework. The supporting framework is of an integral structure and is rotationally connected with the wheels. The first position sensor is used for sensing the stress information of the two footrest devices relative to the supporting framework. The control device controls a driving device to drive the wheels to move or rotate according to the stress information. A wheel axle is arranged between each wheel and the vehicle body. The wheels are rotationally connected to the vehicle body through the wheel axles. The gravity center of the vehicle body is lower than that of the wheel axles. Thus, when the man-machine interaction somatosensory vehicle is in an operating or non-operating state, the vehicle body is not prone to being overturned.