The invention provides a method and a device for avoiding communication interference. The method is applied to a hierarchical heterogeneous network comprising macro base stations configured by adopting a low frequency band, small base stations configured by adopting a high frequency band, and a vehicle-mounted terminal. Each macro base station covers multiple small base stations, the small base stations in the hierarchical heterogeneous network are in same frequency networking, the supported communication modes are V2C (Vehicle to Cloud) and V2V (Vehicle-to-vehicle), and V2C resources and V2V resources adopt frequency division multiplexing modes. The method comprises the step in which the macro base station configures the same V2C and V2V resource division range information for all small base stations. The communication reliability in an automatic driving application scene can be ensured.