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发明公开
CN106813965A 具有肿瘤细胞染色的裸眼可视纳米微粒制备及微粒和应用 失效 - 权利终止

具有肿瘤细胞染色的裸眼可视纳米微粒制备及微粒和应用
摘要：
本发明提供了一种可以浸染恶性胶质瘤细胞并使其裸眼可视的纳米微粒制备方法及应用。所述纳米微粒是赖氨酸小分子在反相微乳液中经京尼平交联聚合反应得到的，叶酸靶向纳米微粒是由接枝叶酸的赖氨酸化合物在反相微乳液中京尼平交联聚合反应得到。该纳米微粒可特异性浸染恶性胶质瘤细胞，借助自身较强的细胞染色功能，使恶性胶质瘤细胞裸眼可视。
摘要（英）：

The invention provides a preparation method and application of nanometer particles capable of dip-dyeing malignant glioma cells and making the malignant glioma cells visible by naked eyes. The nanometer particles are made from lysine micromolecules in a reversed-phase microemulsion through a cross-linking polymerization reaction with genipin, and folic acid targeting nanometer particles are made from a folic-acid-grafted lysine compound in a reversed-phase microemulsion through a cross-linking polymerization reaction with genipin. The nanometer particles can specifically dip-dye malignant glioma cells and make the malignant glioma cells visible by naked eyes by means of its great cell dyeing function.

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