The invention belongs to the field of medical chemistry, and relates to a heterocyclic compound and application thereof. Concretely, the invention provides a compound as shown in a formula I, or an isomer, pharmaceutically acceptable salts, and a solvate thereof, or a prodrug, a preparation method thereof, a medicine composition containing the compounds, and application of the compounds or the composition in medicines for treating virus infective diseases. Part of the compounds provided by the invention has a better capability of resisting HCV (Hepatitis C Virus), and has the prospect of becoming an HCV therapeutic agent.