The invention relates to a targeted medicine-carrying silica body as well as preparation and application thereof. The preparation comprises the steps of synthesizing a silica body raw material, preparing a targeted liposome raw material, and preparing targeted lipid inserted silicon composite body. The application is cross application of a liposome technique and an inorganic particle carrier technique. A synthesized silica body material is composited with the targeted liposome material, silicon is hydrolyzed outside a medicine to form a shell layer, liposome containing different targeted groups forms an outer shell layer, and therefore, the targeting aiming at different tumor tissues is realized by virtue of a composite mechanism. The invention provides a cladding method of the silica body having a targeting effect and the advantages of good stability, high biocompatibility, long slow release time and high drug loading capacity and medicine coating capacity.