The invention discloses an insecticide used in a mulberry planting process, wherein the insecticide is prepared from the following raw materials in parts by weight: 25-35 parts of nitraria tangutorum bobr., 25-35 parts of puccinellia chinampoensis, 20-25 parts of limonium bicolor, 15-18 parts of cortex meliae, 15-18 parts of common threewingnut root, 8-12 parts of sulfur, 8-12 parts of lycoris radiata, 4-6 parts of Chinese honeylocust fruit, 1-3 parts of schisandra chinensis, and 1-3 parts of succus bambusae; and provided is a preparation method of the insecticide. The insecticide and the preparation method thereof have the beneficial effects that according to the insecticide used in the mulberry planting and the preparation method thereof provided by the invention, the insecticide can effectively kill pests in a mulberry planting process, the mulberry pest rate is increased by 20% than the mulberry pest rate without spraying of the insecticide and is increased by nearly 10% than that of commercially available same-kind products through contrast verification; and the market prospect is good.