The invention discloses an information security control method for mobile equipment. The method includes the steps that a probe detector is installed in a management and control area, a safety monitoring door is arranged at the entrance/exit of the management and control area, when a person passes through the safety monitoring door to enter the management and control area, the safety monitoring door detects whether the person entering the management and control area carries a mobile device or not, security personnel judge whether the mobile device is legal or not, the probe detector is used for real-time monitoring, management and control of mobile device in the management and control area to prevent the person entering the management and control area from neglecting to load or unloading a information security management client, and thus the information safety in the management and control area is ensured. By arranging the information security management client on the mobile device, the distinctive and personalized management of mobile phone use permission is achieved, the information safety is ensured, and at the same time, the normal communication demand of the person in the management and control area is met.