The invention discloses antiseptic and rotproof release tissue paper, prepared from the following raw materials in parts by weight: 200-300 parts of bamboo rods, 130-190 parts of softwood pulp, 100-160 parts of wheat straw, 50-80 parts of organic silicon quaternary phosphonate, 40-80 parts of gelatin, 50-90 parts of modified tapioca flour, 20-36 parts of carboxymethyl cellulose, 30-46 parts of talcum powder, 21-37 parts of paraffin, 40-60 parts of acrylic resin, 12-26 parts of carbonate groups, 6-8 parts of toluene, 30-60 parts of sodium sulfite, 20-38 parts of ammonium hydroxide and 20-38 parts of potassium hydroxide. The antiseptic and rotproof release tissue paper has thin and uniform thickness, good water absorbency, difficulty of rot and bacterium breeding and good flexibility.