The invention discloses a wet separation device of a catalyst. The wet separation device of the catalyst comprises a screen, air outlets, a housing, suction fans, a waste channel, second atomization sprayers, a second water supply pipe, a waste collection device, a waste recycling port, a conveyor belt, a finished product discharge outlet, a vibration motor, a collection hopper, a grating plate and damping springs, wherein a feed inlet is formed in the left side of the housing; the screen is arranged on the top of the grating plate; the damping springs are arranged at the two ends of the bottom of the grating plate; the collection hopper is arranged at the bottom of the grating plate and provided with the vibration motor; the finished product discharge outlet is formed in the bottom of the collection hopper; the air outlets are formed in the top of the housing and provided with the suction fans; and the second atomization sprayers are arranged on the top of an inner cavity of the waste collection device and connected with the second water supply pipe. The wet separation device of the catalyst can effectively remove dust generated in the separation process of the catalyst, pollution is eliminated, integration of the catalyst can be maintained, and the product quality can be improved.