The invention discloses an apremilast quick-release pellet preparation and a preparation method, and relates to the fields of a pharmaceutic preparation technology and application. The apremilast quick-release pellet preparation has an administration mode of oral administration; the apremilast quick-release pellet preparation is characterized in that a blank core pellet is used as a carrier, an apremilast water solution prepared from a cosolvent and an adhesive is used as an administration solution, and the dosage of the apremilast water solution accounts for 0.0025 to 0.3 percent of that of the blank core pellet according to a weight ratio; the oral dosage of the apremilast water solution is not higher than 50 mu g. The apremilast quick-release pellet preparation disclosed by the invention has the characteristics of high administration rate, good content uniformity, rapid drug release, quick analgesic effect, and the like; meanwhile, the apremilast quick-release pellet preparation has the characteristics of good clinic use compliance, high safety and the like; in addition, a blank core pellet fluidized bed administration method is suitable for preparation of apremilast drug oral preparations in very low specifications.