The invention discloses a hollowed-out gold mark and a gold mark location device. The hollowed-out gold mark comprises a gold mark main body, wherein a first through hole is formed in the gold mark main body along an axis of the gold mark main body; the gold mark main body is hollowed-out; a plurality of drug sustained release boxes are kept in the first through hole; a plurality of second through holes are formed in the gold mark main body in a radial direction of the gold mark main body; and the gold mark main body is of a hollowed-out structure. According to the hollowed-out gold mark provided by the invention, the gold mark main body is represented as the hollowed-out structure through the second through holes in the gold mark main body, so that the stability of the gold mark main body and tumor tissues or surrounding special soft tissues thereof where the gold mark main body is implanted is enhanced, and subsequently, the gold mark main body is prevented from moving easily, detection precision is enhanced and the accuracy of a detection result is guaranteed; and by keeping the plurality of drug sustained release boxes in the first through hole, treatment on patients is facilitated; and the hollowed-out gold mark has the advantages of being simple in structure, convenient to use and the like.