The invention discloses a pressure calibration device, which comprises a pressing module, a profiling module and a communication line switching module. The profiling module is used for placing a device for being subjected to pressure calibration. The pressing module and the profiling module are in press fit with each other so as to calibrate the pressure of the device for being subjected to pressure calibration. The profiling module is provided with a through hole. The communication line switching module is assembled in the through hole and is used for switching and delivering the pressure calibration data of the device for being subjected to pressure calibration during the pressure calibration process. The communication line switching module comprises a communication line switching part. The two ends of the communication line switching part is provided with communication line interfaces in a direction parallel to the axial direction of the through hole in the profiling module. The communication line interfaces at the two ends of the communication line switching part are mutually in communication connection. By the pressure calibration device provided in the invention, the airtightness of the connection part of the receiving cavity of the profiling module with a USB communication line is ensured.