The invention discloses a laser cleaning device and method for a multi-hole reticulate structure object. The laser cleaning method comprises the following steps that a three-dimensional model of a to-be-cleaned multi-hole reticulate structure object is obtained through a model obtaining unit; the three-dimensional model is treated by a model treatment unit, a multi-hole area and an entity area are obtained after dividing, and the laser cleaning parameters of the multi-hole area and the entity area are set up correspondingly; several groups of processing layer data are generated and stored in a database; and the processing layer data in the database are read by a parameter reading and outputting unit and output to a three-dimensional dynamic focus scanning system, and according to the processing layer data, the multi-hole area and the entity area are subjected to distinctive laser cleaning by the three-dimensional dynamic focus scanning system. According to the laser cleaning device and method for the multi-hole reticulate structure object, since the multi-hole area is subjected to fine cleaning, and the entity area without holes is subjected to fast cleaning, thorough cleaning of meshes is guaranteed, and cleaning efficiency is also improved.