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发明授权
CN106488928B 具有抗炎症、骨形成及生发促进活性的肽及其的用途 有权

具有抗炎症、骨形成及生发促进活性的肽及其的用途
摘要：
本发明提供由选自由序列表中序列1、序列表中序列2及序列表中序列3的氨基酸序列组成的组中的一种氨基酸序列形成的具有抗炎症及骨分化促进活性的肽。本发明提供由选自由序列表中序列1及序列表中序列2的氨基酸序列组成的组中的一种氨基酸序列形成的具有生发促进活性的肽。本发明的由序列表中序列1、序列表中序列2或序列表中序列3的氨基酸序列形成的肽抑制炎性细胞因子的表达并抑制炎症细胞的增殖，结果呈现出抗炎症活性，且使参与骨形成的磷脂酰肌醇3‑激酶、Smad1、Smad5及Smad8的磷酸化增加，并使碱性磷酸酶、骨保护素及骨唾液酸蛋白的表达增加，结果促进骨分化。本发明的由序列表中序列1或序列表中序列2的氨基酸序列形成肽促进毛囊细胞及脐静脉内皮细胞的增殖，且使细胞外信号调节激酶的磷酸化增加，并使作为参与毛发生长的蛋白质的磷脂酰肌醇3‑激酶、β‑链蛋白、胰岛素样生长激素‑1、角质细胞生长因子、Wnt3a的表达增加，且使作为脱发基因的DKK‑1的表达减少，结果呈现出脱发预防及生发促进功效。
摘要（英）：

Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions. And a peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, consequently shows efficacy for preventing hair loss and promoting hair growth by promoting proliferation of hair follicle cells and human umbilical vein endothelial cells, increasing phosphorylation of EPK, increasing expressions of PI3K, ²-catenin, IGF-1, KGF and Wnt3a which are proteins that contribute to hair growth, and reducing an expression of DKK-1 which is a hairless gene.

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